RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. Transforming protein RhoA, also known as Ras homolog family member A ( RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. positive regulation of T cell migration.regulation of neural precursor cell proliferation.regulation of modification of postsynaptic actin cytoskeleton.regulation of modification of synaptic structure.positive regulation of leukocyte adhesion to vascular endothelial cell.positive regulation of vascular associated smooth muscle contraction.negative regulation of reactive oxygen species biosynthetic process.positive regulation of NIK/NF-kappaB signaling.negative regulation of oxidative phosphorylation.positive regulation of podosome assembly.cellular response to lipopolysaccharide.regulation of microtubule cytoskeleton organization.positive regulation of alpha-beta T cell differentiation.positive regulation of smooth muscle contraction.positive regulation of vasoconstriction.negative regulation of neuron differentiation.establishment of epithelial cell apical/basal polarity.positive regulation of neuron apoptotic process.negative regulation of neuron apoptotic process.positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.negative regulation of I-kappaB kinase/NF-kappaB signaling.negative regulation of intracellular steroid hormone receptor signaling pathway.stress-activated protein kinase signaling cascade.establishment or maintenance of actin cytoskeleton polarity.positive regulation of actin filament polymerization.forebrain radial glial cell differentiation.negative regulation of neuron projection development.regulation of neuron projection development.negative regulation of cell-substrate adhesion.regulation of actin polymerization or depolymerization.
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